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Matthew Nichols, M.D.
in Denver

About Matthew Nichols, M.D.

Dr. Matthew Nichols obtained his undergraduate degree at Rice University in Houston, Texas, and went on to receive his medical degree at the University of Texas Medical Branch in Galveston, where he graduated with honors and was elected to the Alpha Omega Alpha honors society. He then completed his internship and residency in Internal Medicine at the University of Colorado Health Sciences Center.

After conducting a year of basic science research, Dr. Nichols continued his training as a Gastroenterology and Hepatology Fellow at the University of Colorado, where he served as Chief Fellow in 2006. His areas of special interest include the management of inflammatory bowel diseases and esophageal disorders.

Dr. Nichols is the primary investigator for a number of research studies focusing on new therapies for ulcerative colitis and Crohn’s disease. Dr. Nichols is actively involved in the Rocky Mountain Chapter of the Crohn’s and Colitis Foundation (CCF), and has been the physician sponsor for the south metro CCF support group since 2007.  He has served on the CCF Advisory Board, South Denver GI executive committee, and was medical director of Ridge View Endoscopy Center for 10 years. He was awarded the Rocky Mountain CCF Volunteer of the Year award in 2011 and was the Rocky Mountain CCF Physician Distinction Award recipient in 2015. 

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Patient Care Philosophy

For patients, decisions about best therapy and approach for Crohn’s disease or ulcerative colitis can be difficult, and at times scary. These decisions cannot be rushed or forced. My goal is to establish a close relationship and dialogue with my patients, where there can be an open conversation about questions, concerns and goals. I focus on education about options, with the patient always driving all decisions, working together to craft a personalized, tailored and optimized therapy and treatment plan, to encompass best medical options, as well as complementary managements.

Clinical Expertise

Management of inflammatory bowel diseases
Esophageal disorders
Gastroesophageal reflux disease (GERD) 


Rice University, BA
University of Texas Medical Branch at Galveston, MD, with Honors
University of Colorado Health Sciences Center, Residency, Internal Medicine
University of Colorado Health Sciences Center, Fellowship, Gastroenterology

Board Certifications and Societies

American Board of Internal Medicine, Gastroenterology
American Society of Gastrointestinal Endoscopy

Associations and Memberships

American Association for the Study of Liver Diseases
Crohn’s and Colitis Foundation
American Gastroenterological Association

I very much appreciate Dr. Nichols' ability to listen, understand challenges and provide support and guidance to my on-going health and well-being. Thank you!!

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Dr. Nichols has a calm and reassuring manner. He seems genuinely invested in my well-being.

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Dr Nichols is awesome! So personable and caring!

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South Denver GI Locations

Lone Tree Clinic

10103 Ridge Gate Parkway, Suite 312A Aspen Building Lone Tree, CO 80124

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P: 303.788.8888
F: 866.456.4594

Ridge View Endoscopy Center

10103 Ridge Gate Parkway, Suite 312B Aspen Building Lone Tree, CO 80124

Get Directions
P: 303.788.8888
F: 866.456.4594